I have one for my G4 tower and it works a treat right out of the box.
For a laptop, look into the Kensington Pocket Mouse Pro. The cable reels into the mouse case when not in use. I've gone through two of them already on my TiBook, though, so they could probably be sturdier. (Or I could just treat them with more care, I suppose.)
My wife still likes the Apple Pro ('crystal) mouse since she can't remember when to click which button on a multi-button mouse. She also has MS with accompanying loss of manual dexterity and the Apple mouse is essentially one big mouse button so you just squeeze it anywhere to click.
Takes all kinds, I say.