Can you still get OS/2 to work with all the new hardware?
Define the hardware.
If you stay with mainstream manufacturers, the odds are quite high. If you go with just pulling shit out of a bin with no prior research, you're in for an extremely painful experience.
As one who has to have nearly all of his hardware working across the 4 Oses that are installed on this box, I didn't go into this without forethought. With the possible exception of PCDOS, I've got everything in this 3 year old box working in every OS. While none of it is considered top end today, it was (at the time I build it) fairly close.
Warp 4 and eCS are only held hostage by the OEMs. If they don't make drivers, you've got a long road to hoe unless soemone can port Linux drivers (if they exist) to OS/2. That has been done, but only by a few people with the time, resources, and passion not to give up on OS/2.
The time has long past to expect anything from IBM as far as driver support for OS/2 is concerned. If their business clients don't need it, then they won't make a driver for it. And even if they do make a driver, chances are that unless you have a subscription to a support contract, you can't get it anyway. I don't know too many home users of OS/2 that can afford to fork over several hundred or thousands of dollars to get a driver written.
The OS/2 community waited far too long for handouts and scraps from the IBM table when it should have been taking matters into its own hands. Sorry for rambling on, but it's times like this when I think it's too late to stop the decline (and death) of OS/2.