I've been an avid skydiver since 1983. I've got over 24 hours of free fall time and over 1000 jumps (which means I've fallen something like 1500 miles).
When I started in the sport, before standardization of equipment, the number one cause of deaths wasn't "failed parachutes" (which was maybe 5% of problems - and today its less than a whole percent). It was "borrowed gear".
Every month I would eagerly rip open my new issue of Parachutist to read the accident reports - because its valuable (and safer) to learn from other people's mistakes.
In the early 80's skydiving was going through a transition period from outlaw practice to viable busineess. While lots of military surplus gear was still common, the first gear created strictly for pleasure jumping was beginning to appear on the market from a half dozen different companies.
The result was stuff shipped with a wide variety of "user interfaces" (handle placements). Some put the main deployment handle on a band crossing the belly. Other s on the left hip, or the right hip. The bottom of the pack was a common place while older gear had the main rip cord on the chest. Reserve ripcords were typically on the chest next to the cutaway handle for separating from the main parachute (if its trash you want it gone before opening old faithful) but left and right placement varied. Handle appearance varied as well. So you couldn't just grab a rig and know whats what. You had to ask the owner. I mean, if you don't know what it is, maybe you shouldn't jump it.
But people sometimes borrow gear because their stuff isn't packed when the plane is ready to go. So very knowledgeable skydivers would borrow something, get a quick explanation for what was where, (there's only 3 handles on a parachute, main, reserve, cutaway), and go make a jump.
And then they'd hit the ground pulling on the wrong thing. Lots of them. Gurus. Guys who had jumped everything under the sun and were as comfortable freefalling as lying in a hammock would bounce. The investigation would typically find that the guy was jumping something he had borrowed on the spur of the moment.
This cycle is repeating among the BASE jumping community as BASE gear evolves. You may remember the news story from a couple years ago of Jan Davis - one of the best and brightest - very publicly bouncing during a protest jump at Yosemite in 1999. The park officials were going to arrest the participants and confiscate their gear - so she borrowed something less nice than her regular rig. The unfamiliarity killed her (it wasn't lack of knowledge - she knew how it worked - she had hundreds of jumps on it).
The moral of this story is that variety kills. Today every single rig on the market has the handles laid out in exactly the same way and we don't have those kinds of accidents anymore. So for the same reason, I think its dangerous to mix file system types on a computer. At least until the tools evolve to properly handle the issues.
If the handles on the different file systems are different, accidents will happen.
Better knowledge is not the answer. Standardizing the interfaces is. All tools must become multi-file sytem aware or as Arkadiy says - we might as well keep sector maps on a pad of paper by our desk.
Of course, you seem to think you're bulletproof and your "knowledge" will protect you. It won't. You'll forget what file system you're on one day and slip. Like all those former skygods I used to know.
The dead ones.