That looks and sounds like a programming error. I haven't seen anything like that, but I don't go editing my options very often either.

Add a bug report to the Suggestions forum, tell us which browser you were using, what steps you took, which screen you were on, what the selected and unselected options were, etc. If you really want to give us some good information on how to help us fix it, read this, and follow the instructions in there: http://www.joelonsof...og0000000029.html