amavisd-new is a high-performance interface between mailer (MTA) and content checkers: virus scanners, and/or SpamAssassin. It is written in Perl for maintainability, without paying a significant price for speed. It talks to MTA via (E)SMTP or LMTP, or by using helper programs. Best with Postfix, fine with dual-sendmail setup and Exim v4, works with sendmail/milter, or with any MTA as a SMTP relay. For Courier and qmail MTA integration there is a patch in the distributed package.