I have everything setup in X, so that the 1280x1024 Firefox, OO.o Writer and so on have the same actual size on the 1600x1200 screen.
Now, if I went to 2048x1536... even for *ME* that is quite a bit smaller than I;d like. 1920x1440 was small as well.
I don't envy anyone needing 1280x1024 @ 21" size. Yikes.