Not "big" stuff - it appears to moi (nessun reclamo ad essere un erudito di Bugatti) that he -unlike the Little autistic Twerp- was an actual innovator.

Ex:
In many (most?) of his engine designs as featured 'normal' (not OHC or DOHC) cam + follower: he elected to make the cam-follower SQUARE, not the ever-so-much simpler (and obvious) round - as lends itself to ez hole-drilling for its receptacle.

But when one looks at the actual forces on this part, and examines the wear patterns of the round version: one sees that SQUARE maximizes the resistance-to-wear of this part as is constantly being rubbed-sideways by the cam lobe. More importantly - also minimizes er 'circular aberrant wear?' on the cam lobes themselves.

In an era of seat-of-pants metallurgy and considering the expense of new cams and ancillary parts (and labor) -- the extra time for a competent technician to Just Once (at construction) scrape-square the bore, after its babbit was poured: was a sane engineering decision. A perfectionist decision, but not a gratuitous one.

(Tales of the ~'reason' for La Royale specifically, notwithstanding.)
The Type 57SC (supercharged) most assuredly displayed conoscenza completa ... of the power/weight metric of Going Fast.

(Though he also reputedly said..)
Brakes? What are Those !? I make my cars to GO not to STOP!!!


Carrion

And would love to have heard his objections.

Don't think they'd spawned wire-wrapped rubber hoses yet ?? To play Debbil's advocate.. Imagine trying to make your own.