Kerry was married to Julia Thorne in 1970, and they had two children together. Alexandra Kerry was born on September 5, 1973, days before Kerry began law school. She graduated in June 2004 from a film school in the Los Angeles area. Vanessa Kerry was born on December 31, 1976. She is a graduate of Phillips Academy (like her grandfather) and Yale University, and is currently a student at Harvard Medical School. Vanessa has been active in her father's Presidential campaign.

In 1982 Thorne, who was suffering from severe depression, asked Kerry for a separation. [13] They were divorced on July 25, 1988. "After 14 years as a political wife," she wrote in A Change of Heart, her book about depression, "I associated politics only with anger, fear and loneliness." The marriage was formally annulled by the Roman Catholic Church in 1997. Thorne later married Richard Charlesworth, an architect, and moved to Bozeman, Montana, where she became active in local environmental groups such as the Greater Yellowstone Coalition. She has announced that she is "100% behind" Kerry's candidacy for President.