Sin of pride, man. Not knowing your place in the big picture.
It wouldn't matter, but it can cause you to fuck up in the little picture. And the little picture matters a great deal. Fall of the sparrow. Hell, the little picture is all that really matters. If the big picture didn't mess with lots of little pictures, would geopolitics matter more than a drunken game of Risk(tm) played by a bunch of assholes you don't know personaly?
Detatch your emotions from what isn't really yours, so you can connect to what really is yours. Be aware and informed about the big picture, because it matters, but save your energy for whatever challenge you are facing tomorrow morning. You aren't going to straighten out Israel and the Arabs, no matter how hard you think and feel. But you might make somebody's day worth living - maybe even yours - or not.
Don't waste your buzz on the big picture players. There is some person who you will have an insignificant encounter with tommorow who matters more. Save your energy to give that person a smile or a wise word or a fat lip and so that you know which is needed.