Go for it young man.
Be daring and run unstable.
It's a beautiful experience living on the edge :)
My desktop has been happily chugging along with the unstable distro for ages without too many glitches.
However, it does result in rather large updates every week.
Not only that I'm running xfree86 4.3 which is classified as an experimental package as 4.2 doesn't properly support my new graphics chipset :(
And just for a bit of extra fun I've got kernel 2.6 running.
It's sweet.