Aspirin is the only painkiller not based on grapes to which I ever have recourse, and that very seldom. I used to treat bad colds by quadrupling the recommended dose of Nyquil (which didn't really do anything for the symptoms, but which rendered me woollily indifferent* to them) until I understood the folly** of that thirty years ago.

cordially,

*Sort of like nitrous oxide in dentistry. Last time I went in for major sandblasting I opted for the gas. I registered that discomfort was occurring, but it was more like reading about an ordeal undergone by someone else, far away and a long time ago.

**I was raising to my lips the sixth little plastic cup of that vile green fluid that day when a gag reflex took hold. I lowered the cup; the reflex subsided. Raised the cup, gagged; lowered it, no gag. Repeated the ritual two or three times, concluded "My body really, really wants to convey something important," and never took Nyquil or any related remedy again.