It can make a mess out of file permissions on NTFS. We use it to back up the configuration of a set of Linux gateways to a Windows server in reach of Backup Exec. When run as the local system account, the repository created by the DeltaCopy server does not inherit the permissions it should from its parent directory. You'll have to periodically go in, grab ownership of the lot and reset the permissions.

It may behave different when run as a regular user account but we have not tried that yet.