Specifically, under Wine. According to Google and WineHQ, this is Very Difficult.

Which is a bummer as there is a piece of software I'd like to use that was built against dotNet 3.5 SP1 (it's the DnD Character Builder). No, WotC have shown no inclination to change this requirement.

What I'm asking is is there anyone here who has tried this? And how far did you get? The Wine docs suggest that it might actually be possible, despite the odds, but there are a lot of traps along the way.

Wade.