Ibogaine ...

http://en.wikipedia.org/wiki/Ibogaine

(Probably not your experimental substance wayback; this one's now trying to be groomed as an anti-)
And natch, Puritamerica has proscribed the sucker, rendering US basic research flaccid;
meanwhile all those suburban methheads gone blooey in their desperate search to Somehow Got Outta the Murican experience ... await deliverance. (No, not That one. Prevert.)

But they can still go to Mexico, when it's time to come down and face the mouthbreathers.
Alkaloids.. the perfect companion to The Botany of Desire, that masterpiece of infosatire of the biped hubris experience:

Yes, Virginia, plants Are smarter than people.