In a word: yes
orphaner produces a list of packages that are installed on your system, but that nothing else that is installed on your system relies upon. Therefore, it is safe to remove these packages. It is possible that you will remove all those packages, and then those packages you just removed will make other packages orphans. The orphaner package will automatically run itself multiple times until there are no packages remaining which are orphaned.
-YendorMike
"They that can give up essential liberty to obtain a little temporary safety deserve neither liberty nor safety."
- Benjamin Franklin, 1759 Historical Review of Pennsylvania