Not exactly a hand held, but these Palm Pilot like remote controls are pretty slick. The [link|http://www.remotecentral.com/tsu2000/index.html|Pronto TSU2000] has a 4 greyscale display while the [link|http://www.remotecentral.com/prontopro/index.html|Pronto Pro] has a 256 color display.
The remotes are fully customizable - hit a single "watch DVD" button and a macro runs that will turn on the TV and switch to the DVD video input, turn on the surround sound decoder and switch to the DVD audio input, turn on the DVD and then change the remote's display over to the DVD control panel.
Here's a few [link|http://www.remotecentral.com/prontopro/winapro.htm|examples] of customization from a contest. I like the idea of using channel logos to pick your station(see 3rd image of grand prize winner).
While pricy compared to other "all-in-one" remotes, these can actually make your home theater easy to use(for wife, visiting family, etc) via some macro programming.