There was a time when there were raging debates over whether neutrinos were only an accounting trick.
Then we figured out how to detect ones coming from astronomical objects. (Leaving the question of how to account for why we only see 1/3 of what we expect to from the Sun.) As a result, if they thought they had detected this, I would be inclined to believe that it really existed. The addition of one more practically invisible particle (which is practically invisible for understood reasons) is less of a shock than revocation of conservation of energy.
However whether or not we would accept this as yet undetected particle is irrelevant to QM. At present we have tremendous amounts of information supporting the basic concepts of QM. Even if QM turns out to be fundamentally wrong it, like Newtonian physics, is going to survive as a heck of an approximation.
Now if you argued that the idea of supersymmetry was like epicycles, I would be less inclined to disagree. It does, after all, predict a bevy of particles we haven't seen at energies we can't reach without a heck of a lot of concrete evidence. Heck, even if it is right, I happen to think that that area of physics is one of rather little interest at present. (See [link|http://z.iwethey.org/forums/render/content/show?contentid=20256|my rant] a while ago on this.)
But supersymmetry is not QM. It is an attempt to push QM ever closer to the Big Bang. Its success or failure has little impact on the larger theory of QM. Even if it fails, we will still be using QM in understanding the materials properties that allow us to keep pushing Moore's law forward...
Cheers,
Ben