None of them seem idiotically simple to use, but I'm guessing these are command line utilities and you just want a GUI to configure arguments and display results nicely.

You can use any GUI toolkit you know how to use and interact with your perl programs via the equivalent of "system".

If you want a web solution and will stick with perl look at mason.
If you know VB and its windows, use that and whatever command line exec capability it has.
If you want cross platform basic, try RealBasic.
Use Squeak and call your perl via OSProcess - either the Squeak GUI or Seaside web gui.
Use Cocoa and use NSTask if its a Mac.
Use bloody Java and Swing with System.exec()

Fronting command line tools is easy and similar facilities exist in any language - pick one that has a GUI api you can handle.

Sheesh.