Depends upon the goal desired:

1) Reduce to quivering mass of blubbering Jello.

2) Do 1) adding: attack Kidneys, via immune system response.
2a) Just make them want to urinate. A Lot.
2b) Commence shut-down of, 2b-1) One? or, 2b-2) Both?

3) The resonant frequency of the anal sphincter is ~ 54 Hz
(This method requires a little equipment, along with The Message)

There are Individual Rates and Group Buy
(as say, the Knitting Ladies, in Python sketches.)

For quotations:
Send psychiatric report and your naked color photo to -


Serendipitous Sanctimony Remedies LLC
Div. of Up Yours! Proctologists Ltd.