UNIX Shops run.

The only thing you have to be sure about, if someone has multiple machines in the same room and uses certain Apps, some apps will report the default profile/setting/tempsomething is being used by another machine "{machine addr or name}" please use a different profile.

I have done this for years at home and work. I have Windows users using the *NIX homedir as their SAMBA homedir. Works fine by me.