Has something changed on your ISP's SMTP server? Some antispam setting perhaps? Is your mailbox full?
Maybe [link|http://www.mailsbroadcast.com/email.bolts&nuts/smtp.return.codes.error.htm|this] will help you debug it. It seems to be on the server side, if I'm skimming things correctly.
HTH. Luck!
Cheers,
Scott.